Diclofenac takes 20 to 30 minutes to work if you take it as tablets or capsules. Suppositories take a few hours to work. There's no difference in how well the tablets, capsules or suppositories work. High doses or prolonged use of diclofenac, a commonly prescribed non-steroidal anti-inflammatory drug (NSAID), may result in gastrointestinal complications, which, if ignored, can be fatal. A preventable death attributed to diclofenac in a 16-year-old girl with complex needs has been identified, and is described in this article. Adverse drug reactions from NSAIDs should be considered and Diclofenac or diclofenac sodium is a drug with potential anti-inflammatory effects, relief of muscle aches, and symptoms of arthritis. Diclofenac sodium is a non- steroidal medicine . Its side effects and contraindications are mild and generally associated with the digestive system. Diclofenac is usually prescribed as a tablet or cream. Diclofenac sodium is indicated for the treatment of signs and symptoms of osteoarthritis of the knee (s) (1). ( 1) · Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals. ( 2) · The recommended dose is 40 drops on each painful knee, 4 times a day. Diclofenac Sodium Side Effects. Common side effects include heartburn,constipation, diarrhea, unexplained bleeding, ulcers in the stomach or intestines, gas, nausea, vomiting, stomach pain, dizziness, swelling, headache, itching, ringing in the ears or unexplained rash. These side effects occur in up to 10 percent of users. Diclofenac (Topical Application Route) Merative, Micromedex. Diclofenac is used to treat pain and other symptoms of arthritis of the joints (eg, osteoarthritis), such as inflammation, swelling, stiffness, and joint pain. However, this medicine does not cure osteoarthritis and will help you only as long as you continue to use it. yellowing of the skin or eyes ( jaundice) Get medical help right away, if you have any of the symptoms listed above. Common side effects of Solaraze Gel include: application site skin reactions (rash, redness, scaling, dry skin, swelling, irritation, or itching), nausea, stomach pain, upset stomach, diarrhea, or. gas. Diclofenac sodium topical gel (DSTG) contains diclofenac sodium as the active ingredient, a white/yellow crystalline powder soluble in ethanol, moderately soluble in water and acetone, and partially insoluble in ether. Diclofenac sodium (C 14 H 10 Cl 2 NNaO 2) is the sodium salt form of diclofenac, a benzene acetic acid derivate with analgesic 9k4kg.